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Preimplantation Genetic Testing (PGT)

Screening embryos for genetic disorders.

Preimplantation Genetic Testing (PGT) – Screening Embryos for Genetic Disorders

At Genesiss Multispeciality Hospital, we provide Preimplantation Genetic Testing (PGT) as part of advanced fertility care. PGT allows us to screen embryos created through IVF for chromosomal abnormalities or inherited genetic disorders before implantation, ensuring that only healthy embryos are selected for transfer. This improves the chances of a successful pregnancy while reducing the risk of passing on genetic diseases to the child.


Problems / Concerns Addressed:

  • Couples with a family history of genetic disorders (e.g., thalassemia, cystic fibrosis, sickle cell anemia).
  • Recurrent miscarriages caused by chromosomal abnormalities.
  • Women of advanced maternal age (higher risk of chromosomal errors).
  • Previous failed IVF cycles due to poor embryo quality.
  • Couples who are carriers of single-gene disorders.

Treatments / Services Offered:

  • Embryo Biopsy – A few cells are safely removed from the embryo on day 5 or 6 (blastocyst stage).
  • PGT-A (Aneuploidy Screening) – Checks for abnormal chromosome numbers.
  • PGT-M (Monogenic Testing) – Detects specific single-gene mutations.
  • PGT-SR (Structural Rearrangements) – Screens for chromosomal translocations or structural issues.
  • Selection of Healthy Embryos – Only genetically normal embryos are transferred to maximize pregnancy success and minimize risks.

FAQs

What is Preimplantation Genetic Testing (PGT)?

PGT is a genetic screening procedure performed on embryos created through IVF to detect chromosomal abnormalities or genetic disorders before transferring them into the uterus.

Who should consider PGT?

PGT is recommended for couples with a family history of genetic disorders, women over 35, those with recurrent miscarriages, or couples with multiple failed IVF attempts.

Does PGT harm the embryo?

No, the biopsy process is safe when performed by experts. Embryos continue to develop normally after the procedure.

How accurate is PGT?

PGT is highly accurate (over 95%) in detecting chromosomal and genetic abnormalities, though final confirmation may require prenatal testing.

Does PGT increase IVF success rates?

Yes, by selecting healthy embryos, PGT improves implantation rates, reduces miscarriage risks, and increases the chances of a successful pregnancy.

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